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Anti-UBA7 Polyclonal Antibody (PTX18696)

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概述
货号PTX18696
品牌ProteoGenix
描述
Anti-UBA7 Polyclonal Antibody (PTX18696) is a rabbit polyclonal antibody detecting D8,Ubiquitin-activating enzyme 7,UBE1L,UBA7,Ubiquitin-like modifier-activating enzyme 7,UBE2,Ubiquitin-activating enzyme E1 homolog in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human UBA7 (Lys429-Val488).
靶标D8,Ubiquitin-activating enzyme 7,UBE1L,UBA7,Ubiquitin-like modifier-activating enzyme 7,UBE2,Ubiquitin-activating enzyme E1 homolog
纯化方式Purified by antigen affinity column.
Accession号P41226
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a ~111 kDa protein. E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation. Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus. For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition. ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling.

1. Park, JH. et al. (2016) Nature communications 7, 12513. PMID: 27545325
2. Lenschow, DJ. et al. (2005) Journal of virology 79, 13974-83. PMID: 16254333
3. Giannakopoulos, NV. et al. (2009) Journal of virology 83, 1602-10. PMID: 19073728
4. Zhao, P. et al. (2017) Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 56, 44-53. PMID: 29056542
5. Lee, MK. et al. (2018) Journal of virology 92. PMID: 29743376
6. Sarkar, R. et al. (2023) Cellular signalling 112, 110891. PMID: 37722521
7. Zhao, C. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 2253-8. PMID: 20133869
8. Kim, YJ. et al. (2016) PLoS pathogens 12, e1005850. PMID: 27564865
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-UBA7 Polyclonal Antibody

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