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Anti-CHRNA4 Polyclonal Antibody (PTX19702)

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概述
货号PTX19702
品牌ProteoGenix
描述
Anti-CHRNA4 Polyclonal Antibody (PTX19702) is a rabbit polyclonal antibody detecting Neuronal acetylcholine receptor subunit alpha-4,NACRA4,CHRNA4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human CHRNA4 (Asn49-Leu242).
靶标Neuronal acetylcholine receptor subunit alpha-4,NACRA4,CHRNA4
纯化方式Purified by antigen affinity column.
Accession号P43681
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4) is a ~69 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system.

1. Bondarenko, V. et al. (2012) Biochimica et biophysica acta 1818, 1261-8. PMID: 22361591
2. Morales-Perez, CL. et al. (2016) Nature 538, 411-415. PMID: 27698419
3. Walsh, RM. et al. (2018) Nature 557, 261-265. PMID: 29720657
4. Mazzaferro, S. et al. (2024) British journal of pharmacology 181, 1973-1992. PMID: 38454578
5. Tumkosit, P. et al. (2006) Molecular pharmacology 70, 1358-68. PMID: 16835356
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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