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Anti-GZMK Polyclonal Antibody (PTX19717)

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概述
货号PTX19717
品牌ProteoGenix
描述
Anti-GZMK Polyclonal Antibody (PTX19717) is a rabbit polyclonal antibody detecting NK-tryptase-2,Fragmentin-3,Granzyme K,GZMK,Granzyme-3,TRYP2,NK-Tryp-2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human GZMK (Ile27-Asn264).
靶标NK-tryptase-2,Fragmentin-3,Granzyme K,GZMK,Granzyme-3,TRYP2,NK-Tryp-2
纯化方式Purified by antigen affinity column.
Accession号P49863
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Granzyme K (GZMK) is a ~28 kDa protein. Serine protease that initiates the GZMK pathway of the complement system, a cascade of proteins directly activated by CD8(+) T-cells that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. GZMK is specifically secreted by CD8(+) T-cells and mediates both recognition and initiation steps of GZMK complement pathway. First acts as a pattern recognition receptor, which specifically recognizes and binds heparan sulfate glycosaminoglycans on the pathogen surface to drive opsonization. It then initiates the complement pathway cascade by catalyzing cleavage and activation of C2 and C4, the next components of the complement pathway. GZMK-mediated complement activation is an important contributor to tissue inflammation.

1. Hameed, A. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 141, 3142-7. PMID: 3262682
2. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882
3. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456
4. Wensink, AC. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 5974-9. PMID: 24711407
5. Mogilenko, DA. et al. (2021) Immunity 54, 99-115.e12. PMID: 33271118
6. Jonsson, AH. et al. (2022) Science translational medicine 14, eabo0686. PMID: 35704599
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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