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Anti-NR1H2/LXRb Polyclonal Antibody (PTX19729)

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概述
货号PTX19729
品牌ProteoGenix
描述
Anti-NR1H2/LXRb Polyclonal Antibody (PTX19729) is a rabbit polyclonal antibody detecting UNR,Oxysterols receptor LXR-beta,LXRB,NR1H2,Nuclear receptor subfamily 1 group H member 2,Liver X receptor beta,NER,Ubiquitously-expressed nuclear receptor,Nuclear receptor NER in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human NR1H2/LXRb (Lys72-Glu460).
靶标UNR,Oxysterols receptor LXR-beta,LXRB,NR1H2,Nuclear receptor subfamily 1 group H member 2,Liver X receptor beta,NER,Ubiquitously-expressed nuclear receptor,Nuclear receptor NER
纯化方式Purified by antigen affinity column.
Accession号P55055
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Oxysterols receptor LXR-beta (NR1H2/LXRb) is a ~50 kDa protein. Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis.

1. Sakurabashi, A. et al. (2015) The Journal of steroid biochemistry and molecular biology 149, 80-8. PMID: 25661920
2. Venteclef, N. et al. (2010) Genes & development 24, 381-95. PMID: 20159957
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-NR1H2/LXRb Polyclonal Antibody

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