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Anti-CASP9/Caspase 9 Polyclonal Antibody (PTX19732)

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概述
货号PTX19732
品牌ProteoGenix
描述
Anti-CASP9/Caspase 9 Polyclonal Antibody (PTX19732) is a rabbit polyclonal antibody detecting CASP9,ICE-like apoptotic protease 6,Apoptotic protease Mch-6,APAF-3,CASP-9,MCH6,Apoptotic protease-activating factor 3,Caspase-9,ICE-LAP6 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human CASP9/Caspase 9 (Lys100-Thr270).
靶标CASP9,ICE-like apoptotic protease 6,Apoptotic protease Mch-6,APAF-3,CASP-9,MCH6,Apoptotic protease-activating factor 3,Caspase-9,ICE-LAP6
纯化方式Purified by antigen affinity column.
Accession号P55211
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Caspase-9 (CASP9/Caspase 9) is a ~46 kDa protein. Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC.

1. Ehrmann, JF. et al. (2023) Science (New York, N.Y.) 379, 1117-1123. PMID: 36758105
2. Dietz, L. et al. (2023) Science (New York, N.Y.) 379, 1112-1117. PMID: 36758106
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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