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Anti-CD322/JAM2 Polyclonal Antibody (PTX19735)

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概述
货号PTX19735
品牌ProteoGenix
描述
Anti-CD322/JAM2 Polyclonal Antibody (PTX19735) is a rabbit polyclonal antibody detecting JAM-B,VEJAM,Junctional adhesion molecule B,JAM2,VE-JAM,JAM-2,C21orf43,Vascular endothelial junction-associated molecule,Junctional adhesion molecule 2,CD322 in ELISA, IHC, WB. Suitable for Human, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human CD322/JAM2 (Tyr74-Val250).
靶标JAM-B,VEJAM,Junctional adhesion molecule B,JAM2,VE-JAM,JAM-2,C21orf43,Vascular endothelial junction-associated molecule,Junctional adhesion molecule 2,CD322
纯化方式Purified by antigen affinity column.
Accession号P57087
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Junctional adhesion molecule B (CD322/JAM2) is a ~33 kDa protein. Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1.

1. Arrate, MP. et al. (2001) The Journal of biological chemistry 276, 45826-32. PMID: 11590146
2. Liang, TW. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 1618-26. PMID: 11823489
3. Arcangeli, ML. et al. (2014) Stem cells (Dayton, Ohio) 32, 1043-54. PMID: 24357068
4. Johnson-Léger, CA. et al. (2002) Blood 100, 2479-86. PMID: 12239159
5. Cunningham, SA. et al. (2002) The Journal of biological chemistry 277, 27589-92. PMID: 12070135
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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