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Anti-PPIA Polyclonal Antibody (PTX18662)

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概述
货号PTX18662
品牌ProteoGenix
描述
Anti-PPIA Polyclonal Antibody (PTX18662) is a rabbit polyclonal antibody detecting PPIase A,Cyclosporin A-binding protein,Peptidyl-prolyl cis-trans isomerase A,Cyclophilin A,PPIA,CYPA,Rotamase A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human PPIA (Val2-Glu165).
靶标PPIase A,Cyclosporin A-binding protein,Peptidyl-prolyl cis-trans isomerase A,Cyclophilin A,PPIA,CYPA,Rotamase A
纯化方式Purified by antigen affinity column.
Accession号P62937
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Peptidyl-prolyl cis-trans isomerase A (PPIA) is a ~18 kDa protein. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation. Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1. Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis. In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2.

1. Liu, J. et al. (1991) Biochemistry 30, 2306-10. PMID: 2001362
2. Davis, TL. et al. (2010) PLoS biology 8, e1000439. PMID: 20676357
3. Song, F. et al. (2011) The Journal of biological chemistry 286, 8197-8203. PMID: 21245143
4. Foster, TL. et al. (2011) Journal of virology 85, 7460-4. PMID: 21593166
5. Lauranzano, E. et al. (2015) Brain : a journal of neurology 138, 974-91. PMID: 25678563
6. Yurchenko, V. et al. (2002) The Journal of biological chemistry 277, 22959-65. PMID: 11943775
7. Jin, ZG. et al. (2004) Arteriosclerosis, thrombosis, and vascular biology 24, 1186-91. PMID: 15130913
8. Xie, Y. et al. (2019) Cellular signalling 61, 57-65. PMID: 31063815
9. Wei, Y. et al. (2013) Inflammation 36, 567-72. PMID: 23180369
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-PPIA Polyclonal Antibody

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