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Anti-PLCB3 Polyclonal Antibody (PTX19747)

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概述
货号PTX19747
品牌ProteoGenix
描述
Anti-PLCB3 Polyclonal Antibody (PTX19747) is a rabbit polyclonal antibody detecting Phospholipase C-beta-3,PLC-beta-3,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3,Phosphoinositide phospholipase C-beta-3,PLCB3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human PLCB3 (Asp318-Lys468).
靶标Phospholipase C-beta-3,PLC-beta-3,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3,Phosphoinositide phospholipase C-beta-3,PLCB3
纯化方式Purified by antigen affinity column.
Accession号Q01970
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (PLCB3) is a ~138 kDa protein. Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Key transducer of G protein-coupled receptor signaling: activated by G(q)/G(11) G alpha proteins downstream of G protein-coupled receptors activation. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses.

1. Waldo, GL. et al. (2010) Science (New York, N.Y.) 330, 974-80. PMID: 20966218
2. Ben-Salem, S. et al. (2018) Journal of medical genetics 55, 122-130. PMID: 29122926
3. Falzone, ME. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2315011120. PMID: 37991948
4. Tall, E. et al. (1997) Biochemistry 36, 7239-48. PMID: 9188725
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-PLCB3 Polyclonal Antibody

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