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Anti-PDE1C Polyclonal Antibody (PTX19783)

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概述
货号PTX19783
品牌ProteoGenix
描述
Anti-PDE1C Polyclonal Antibody (PTX19783) is a rabbit polyclonal antibody detecting PDE1C,Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C,Cam-PDE 1C,3',5'-cyclic-GMP phosphodiesterase,3',5'-cyclic-AMP phosphodiesterase,Hcam3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human PDE1C (Arg284-Asp630).
靶标PDE1C,Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C,Cam-PDE 1C,3',5'-cyclic-GMP phosphodiesterase,3',5'-cyclic-AMP phosphodiesterase,Hcam3
纯化方式Purified by antigen affinity column.
Accession号Q14123
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (PDE1C) is a ~80 kDa protein. Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).

1. Wang, L. et al. (2018) Human genetics 137, 437-446. PMID: 29860631
2. Loughney, K. et al. (1996) The Journal of biological chemistry 271, 796-806. PMID: 8557689
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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