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Anti-MAPRE1 Polyclonal Antibody (PTX18631)

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概述
货号PTX18631
品牌ProteoGenix
描述
Anti-MAPRE1 Polyclonal Antibody (PTX18631) is a rabbit polyclonal antibody detecting EB1,Microtubule-associated protein RP/EB family member 1,MAPRE1,APC-binding protein EB1,End-binding protein 1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human MAPRE1 (Ala2-Tyr268).
靶标EB1,Microtubule-associated protein RP/EB family member 1,MAPRE1,APC-binding protein EB1,End-binding protein 1
纯化方式Purified by antigen affinity column.
Accession号Q15691
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Microtubule-associated protein RP/EB family member 1 (MAPRE1) is a ~29 kDa protein. Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers).

1. Askham, JM. et al. (2002) Molecular biology of the cell 13, 3627-45. PMID: 12388762
2. Hayashi, I. et al. (2005) Molecular cell 19, 449-60. PMID: 16109370
3. Honnappa, S. et al. (2009) Cell 138, 366-76. PMID: 19632184
4. van der Vaart, B. et al. (2011) The Journal of cell biology 193, 1083-99. PMID: 21646404
5. Xia, P. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 16564-9. PMID: 23001180
6. Wei, J. et al. (2017) FEBS letters 591, 2379-2393. PMID: 28726242
7. Yang, C. et al. (2017) The Journal of cell biology 216, 3179-3198. PMID: 28814570
8. Song, X. et al. (2021) Nature chemical biology 17, 1314-1323. PMID: 34608293
9. Radhakrishnan, RM. et al. (2023) The Journal of biological chemistry 299, 102853. PMID: 36592928
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-MAPRE1 Polyclonal Antibody

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