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Anti-CALCRL Polyclonal Antibody (PTX19800)

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概述
货号PTX19800
品牌ProteoGenix
描述
Anti-CALCRL Polyclonal Antibody (PTX19800) is a rabbit polyclonal antibody detecting CGRP type 1 receptor,CGRPR,Calcitonin receptor-like receptor,CALCRL,Calcitonin gene-related peptide type 1 receptor in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CALCRL (Glu23-Glu133).
靶标CGRP type 1 receptor,CGRPR,Calcitonin receptor-like receptor,CALCRL,Calcitonin gene-related peptide type 1 receptor
纯化方式Purified by antigen affinity column.
Accession号Q16602
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Calcitonin gene-related peptide type 1 receptor (CALCRL) is a ~52 kDa protein. G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.

1. Liang, YL. et al. (2020) ACS pharmacology & translational science 3, 263-284. PMID: 32296767
2. Josephs, TM. et al. (2021) Science (New York, N.Y.) 372. PMID: 33602864
3. Aiyar, N. et al. (1996) The Journal of biological chemistry 271, 11325-9. PMID: 8626685
4. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-CALCRL Polyclonal Antibody

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