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Anti-CD301/CLEC10A Polyclonal Antibody (PTX19811)

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概述
货号PTX19811
品牌ProteoGenix
描述
Anti-CD301/CLEC10A Polyclonal Antibody (PTX19811) is a rabbit polyclonal antibody detecting CD301,Macrophage lectin 2,C-type lectin domain family 10 member A,CLECSF13,C-type lectin superfamily member 14,CLEC10A,CLECSF14,HML in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CD301/CLEC10A (Thr71-Met239).
靶标CD301,Macrophage lectin 2,C-type lectin domain family 10 member A,CLECSF13,C-type lectin superfamily member 14,CLEC10A,CLECSF14,HML
纯化方式Purified by antigen affinity column.
Accession号Q8IUN9
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

C-type lectin domain family 10 member A (CD301/CLEC10A) is a ~35 kDa protein. C-type lectin receptor involved in recognition of N-acetylgalactosamine (GalNAc)-terminated glycans by myeloid antigen presenting cells (APCs). Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens, LacdiNAc epitope GalNAcbeta1->4GlcNAc and its derivative GalNAcbeta1->4-(Fucalpha1->3)GlcNAc, O-linked core 5 and 6 glycans, and GM2 and GD2 gangliosides. Acts as a signaling receptor at the interface of APC-T cell interactions. On immature dendritic cells, recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and downregulates PTRPN/CD45 phosphatase activity with an impact on T cell activation threshold, cytokine production and proliferation. Modulates dendritic cell maturation toward a tolerogenic phenotype leading to generation of regulatory CD4-positive T cell subset with immune suppressive functions.

1. van Vliet, SJ. et al. (2005) International immunology 17, 661-9. PMID: 15802303
2. van Vliet, SJ. et al. (2006) Nature immunology 7, 1200-8. PMID: 16998493
3. van Vliet, SJ. et al. (2007) European journal of immunology 37, 2075-81. PMID: 17616966
4. Li, D. et al. (2012) The Journal of experimental medicine 209, 109-21. PMID: 22213806
5. Gabba, A. et al. (2021) Biochemistry 60, 1327-1336. PMID: 33724805
6. Suzuki, N. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 156, 128-35. PMID: 8598452
7. Mortezai, N. et al. (2013) Glycobiology 23, 844-52. PMID: 23507963
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-CD301/CLEC10A Polyclonal Antibody

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