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Anti-PIK3C3 Polyclonal Antibody (PTX19814)

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概述
货号PTX19814
品牌ProteoGenix
描述
Anti-PIK3C3 Polyclonal Antibody (PTX19814) is a rabbit polyclonal antibody detecting PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,hVps34,Phosphatidylinositol 3-kinase catalytic subunit type 3,Phosphoinositide-3-kinase class 3,PI3-kinase type 3,VPS34,PI3K type 3,PIK3C3 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human PIK3C3 (Tyr631-Trp885).
靶标PtdIns-3-kinase type 3,Phosphatidylinositol 3-kinase p100 subunit,hVps34,Phosphatidylinositol 3-kinase catalytic subunit type 3,Phosphoinositide-3-kinase class 3,PI3-kinase type 3,VPS34,PI3K type 3,PIK3C3
纯化方式Purified by antigen affinity column.
Accession号Q8NEB9
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) is a ~101 kDa protein. Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes.

1. Stein, MP. et al. (2003) Traffic (Copenhagen, Denmark) 4, 754-71. PMID: 14617358
2. Chen, YH. et al. (2021) Nature communications 12, 1322. PMID: 33637724
3. Volinia, S. et al. (1995) The EMBO journal 14, 3339-48. PMID: 7628435
4. Zhang, BC. et al. (2020) Nature immunology 21, 868-879. PMID: 32690950
5. Sagona, AP. et al. (2010) Nature cell biology 12, 362-71. PMID: 20208530
6. Thoresen, SB. et al. (2010) Experimental cell research 316, 3368-78. PMID: 20643123
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-PIK3C3 Polyclonal Antibody

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