

| 货号 | PTX19852 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
Anti-SLC40A1 Polyclonal Antibody (PTX19852) is a rabbit polyclonal antibody detecting Solute carrier family 40 member 1,SLC11A3,FPN1,SLC40A1,Iron-regulated transporter 1,IREG1,Ferroportin-1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
|
| 种属反应性 | Human, Mouse, Rat |
| 应用 | ELISA, IHC, WB |
| 宿主 | Rabbit |
| 同种型 | IgG |
| 克隆类型 | Polyclonal |
| 免疫原 | E. coli - derived recombinant Human SLC40A1 (Trp127-Val321). |
| 靶标 | Solute carrier family 40 member 1,SLC11A3,FPN1,SLC40A1,Iron-regulated transporter 1,IREG1,Ferroportin-1 |
| 纯化方式 | Purified by antigen affinity column. |
| Accession号 | Q9NP59 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Ferroportin (FPN1/SLC40A1) is a ~62 kDa protein. Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis. Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes. When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma. 1. Schimanski, LM. et al. (2005) Blood 105, 4096-102. PMID: 15692071 2. Madejczyk, MS. et al. (2012) Biochimica et biophysica acta 1818, 651-7. PMID: 22178646 3. Qiao, B. et al. (2012) Cell metabolism 15, 918-24. PMID: 22682227 4. Mitchell, CJ. et al. (2014) American journal of physiology. Cell physiology 306, C450-9. PMID: 24304836 5. Aschemeyer, S. et al. (2018) Blood 131, 899-910. PMID: 29237594 6. Zhang, DL. et al. (2018) Science (New York, N.Y.) 359, 1520-1523. PMID: 29599243 7. Choi, EK. et al. (2019) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33, 2228-2240. PMID: 30247984 8. Billesbølle, CB. et al. (2020) Nature 586, 807-811. PMID: 32814342 |
| Note | For research use only. |

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