| 背景 | Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a ~107 kDa protein. Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and thus participates in both innate and adaptive immune responses. Specifically recognizes and binds gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), a dipeptide present in peptidoglycan of Gram-negative bacteria. Preferentially binds iE-DAP in tripeptide-containing muropeptides (MurNAc-TriDAP or TriDAP). Ligand binding triggers oligomerization that facilitates the binding and subsequent activation of the proximal adapter receptor-interacting RIPK2. Following recruitment, RIPK2 undergoes 'Met-1'- (linear) and 'Lys-63'-linked polyubiquitination by E3 ubiquitin-protein ligases XIAP, BIRC2, BIRC3 and the LUBAC complex, becoming a scaffolding protein for downstream effectors, triggering activation of the NF-kappa-B and MAP kinases signaling. 1. Inohara, N. et al. (2001) The Journal of biological chemistry 276, 2551-4. PMID: 110586052. Girardin, SE. et al. (2003) Science (New York, N.Y.) 300, 1584-7. PMID: 127919973. Chamaillard, M. et al. (2003) Nature immunology 4, 702-7. PMID: 127967774. Tanabe, T. et al. (2004) The EMBO journal 23, 1587-97. PMID: 150449515. Girardin, SE. et al. (2005) The Journal of biological chemistry 280, 38648-56. PMID: 161721246. Fukazawa, A. et al. (2008) PLoS pathogens 4, e1000228. PMID: 190435607. Lautz, K. et al. (2012) Cellular microbiology 14, 1568-83. PMID: 226722338. Vegna, S. et al. (2016) Journal of virology 90, 6022-6035. PMID: 2709931110. Magalhaes, JG. et al. (2005) EMBO reports 6, 1201-7. PMID: 16211083 |
|---|
