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Anti-PIK3R1/PI3-kinase p85-alpha Polyclonal Antibody (PTX19906)

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概述
货号PTX19906
品牌ProteoGenix
描述
Anti-PIK3R1/PI3-kinase p85-alpha Polyclonal Antibody (PTX19906) is a rabbit polyclonal antibody detecting PI3-kinase subunit p85-alpha,Phosphatidylinositol 3-kinase regulatory subunit alpha,PtdIns-3-kinase regulatory subunit alpha,GRB1,PI3K regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha,PIK3R1,PI3-kinase regulatory subunit alpha in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human PIK3R1/PI3-kinase p85-alpha (Trp624-Val718).
靶标PI3-kinase subunit p85-alpha,Phosphatidylinositol 3-kinase regulatory subunit alpha,PtdIns-3-kinase regulatory subunit alpha,GRB1,PI3K regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha,PIK3R1,PI3-kinase regulatory subunit alpha
纯化方式Purified by antigen affinity column.
Accession号P27986
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1/PI3-kinase p85-alpha) is a ~83 kDa protein. Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.

1. Miled, N. et al. (2007) Science (New York, N.Y.) 317, 239-42. PMID: 17626883
2. Mandelker, D. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 16996-7001. PMID: 19805105
3. Vainikka, S. et al. (1994) The Journal of biological chemistry 269, 18320-6. PMID: 7518429
4. Winnay, JN. et al. (2010) Nature medicine 16, 438-45. PMID: 20348923
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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