Affinity Purified — Minimal background and high purity for reliable results.
Multi-Application — Validated across multiple applications.
种属反应性
Human
应用
ELISA, IHC, WB
宿主
Rabbit
同种型
IgG
克隆类型
Polyclonal
免疫原
E. coli - derived recombinant Human CD172a/SIRPA (Glu31-Arg370).
靶标
BIT,Signal-regulatory protein alpha-1,Brain Ig-like molecule with tyrosine-based activation motifs,MFR,SIRP,Sirp-alpha-1,Sirp-alpha-2,PTPNS1,SIRPA,SHP substrate 1,CD172 antigen-like family member A,Sirp-alpha-3,Inhibitory receptor SHPS-1,Signal-regulatory protein alpha-3,CD172a,Tyrosine-protein phosphatase non-receptor type substrate 1,MyD-1 antigen,Bit,SHPS-1,Macrophage fusion receptor,Signal-regulatory protein alpha-2,SHPS1,MYD1,p84
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Tyrosine-protein phosphatase non-receptor type substrate 1 (CD172a/SIRPA) is a ~54 kDa protein. Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin.
1. Yao, M. et al. (2014) Journal of the American Society of Nephrology : JASN 25, 1171-86. PMID: 24511121
