Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
E3 ubiquitin-protein ligase XIAP is a ~56 kDa protein. Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin.
1. Chai, J. et al. (2001) Cell 104, 769-80. PMID: 11257230
2. Huang, Y. et al. (2001) Cell 104, 781-90. PMID: 11257231
3. Suzuki, Y. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 8662-7. PMID: 11447297
4. MacFarlane, M. et al. (2002) The Journal of biological chemistry 277, 36611-6. PMID: 12121969
