| 靶标 | Renal carcinoma antigen NY-REN-35, p160 ROCK-1, p160ROCK, Rho-associated protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, Rho-associated, coiled-coil-containing protein kinase 1, ROCK-I, ROCK1 |
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| 背景 | Rho-associated protein kinase 1 (ROCK1) is a ~158 kDa protein. Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. 1. Maekawa, M. et al. (1999) Science (New York, N.Y.) 285, 895-8. PMID: 104361592. Ohashi, K. et al. (2000) The Journal of biological chemistry 275, 3577-82. PMID: 106523533. Sumi, T. et al. (2001) The Journal of biological chemistry 276, 670-6. PMID: 110180424. Sebbagh, M. et al. (2001) Nature cell biology 3, 346-52. PMID: 112836075. Hagerty, L. et al. (2007) The Journal of biological chemistry 282, 4884-4893. PMID: 171584566. Shao, J. et al. (2008) Molecular and cellular biology 28, 5196-208. PMID: 185738807. Wang, Y. et al. (2009) Circulation research 104, 531-40. PMID: 191316468. Ishizaki, T. et al. (1996) The EMBO journal 15, 1885-93. PMID: 86172359. Van Eyk, JE. et al. (1998) The Journal of biological chemistry 273, 23433-9. PMID: 9722579 |
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