NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) is a ~43 kDa protein. NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA, MRPL12 and the ATP synthase subunit ATP5PO. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. 1. Schwer, B. et al. (2002) The Journal of cell biology 158, 647-57. PMID: 121868502. Onyango, P. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 13653-8. PMID: 123748523. Schwer, B. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 10224-10229. PMID: 167880624. Schlicker, C. et al. (2008) Journal of molecular biology 382, 790-801. PMID: 186807535. Ahn, BH. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 14447-52. PMID: 187945316. Jin, L. et al. (2009) The Journal of biological chemistry 284, 24394-405. PMID: 195353407. Peserico, A. et al. (2013) Cellular and molecular life sciences : CMLS 70, 2015-29. PMID: 232833018. Bharathi, SS. et al. (2013) The Journal of biological chemistry 288, 33837-33847. PMID: 241215009. Vassilopoulos, A. et al. (2014) Antioxidants & redox signaling 21, 551-64. PMID: 24252090 | 
