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Anti-Human IKBKB Polyclonal Antibody (PTX20100)

概述
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参考文献

概述

货号	PTX20100
品牌	ProteoGenix
描述	Anti-Human IKBKB Polyclonal Antibody (PTX20100) is a rabbit polyclonal antibody detecting IKKB, IKK-beta, Serine/threonine protein kinase IKBKB, I-kappa-B-kinase beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, IKBKB, IKK-B, NFKBIKB, IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, IkBKB in ELISA, IHC, WB. Suitable for Human. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications.
种属反应性	Human
应用	ELISA, IHC, WB
宿主	Rabbit
同种型	IgG
克隆类型	Polyclonal
免疫原	E. coli - derived recombinant Human IKBKB (Glu16-Gly345).
靶标	IKKB, IKK-beta, Serine/threonine protein kinase IKBKB, I-kappa-B-kinase beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, IKBKB, IKK-B, NFKBIKB, IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, IkBKB
纯化方式	Purified by antigen affinity column.
Accession号	O14920
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) is a ~86 kDa protein. Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. 1. Cui, J. et al. (2010) Cell 141, 483-96. PMID: 20434986 2. Tsuchiya, Y. et al. (2010) Molecular cell 39, 570-82. PMID: 20797629 3. Clark, K. et al. (2011) The Biochemical journal 434, 93-104. PMID: 21138416 4. Cardinez, C. et al. (2018) The Journal of experimental medicine 215, 2715-2724. PMID: 30337470 5. Mercurio, F. et al. (1997) Science (New York, N.Y.) 278, 860-6. PMID: 9346484
Note	For research use only.

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参考文献

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

=

浓度

×

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

×

V₁ (起始体积)

=

工作液

C₂ (终浓度)

×

V₂ (终体积)

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Anti-Human IKBKB Polyclonal Antibody

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