Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
N-lysine methyltransferase KMT5A is a ~42 kDa protein. Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis.
1. Nishioka, K. et al. (2002) Molecular cell 9, 1201-13. PMID: 12086618
2. Fang, J. et al. (2002) Current biology : CB 12, 1086-99. PMID: 12121615
3. Yin, Y. et al. (2005) The Journal of biological chemistry 280, 30025-31. PMID: 15964846
