Retinoic acid receptor RXR-alpha (RXRA) is a ~50 kDa protein. Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. 1. Liu, B. et al. (2000) The Journal of biological chemistry 275, 33607-13. PMID: 108740282. Harish, S. et al. (2000) Biochemical and biophysical research communications 279, 853-7. PMID: 111624393. Tsutsumi, T. et al. (2002) Hepatology (Baltimore, Md.) 35, 937-46. PMID: 119150424. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 374788465. Gorla-Bajszczak, A. et al. (1999) Molecular and cellular endocrinology 147, 37-47. PMID: 101956906. Jaye, MC. et al. (2005) Journal of medicinal chemistry 48, 5419-22. PMID: 161071417. Zhao, WX. et al. (2007) Molecular endocrinology (Baltimore, Md.) 21, 2877-89. PMID: 177619508. Chao, EY. et al. (2008) Journal of medicinal chemistry 51, 5758-65. PMID: 1880076710. Lee, DY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 2072-2077. PMID: 28167758 | 
