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Anti-Human CYP2C8 Polyclonal Antibody (PTX20129)

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概述
货号PTX20129
品牌ProteoGenix
描述
Anti-Human CYP2C8 Polyclonal Antibody (PTX20129) is a rabbit polyclonal antibody detecting CYP2C8, Cytochrome P450 MP-12, Cytochrome P450 IIC2, Cytochrome P450 MP-20, Cytochrome P450 2C8, CYPIIC8, S-mephenytoin 4-hydroxylase, Cytochrome P450 form 1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CYP2C8 (Gly40-Val490).
靶标CYP2C8, Cytochrome P450 MP-12, Cytochrome P450 IIC2, Cytochrome P450 MP-20, Cytochrome P450 2C8, CYPIIC8, S-mephenytoin 4-hydroxylase, Cytochrome P450 form 1
纯化方式Purified by antigen affinity column.
Accession号P10632
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cytochrome P450 2C8 (CYP2C8) is a ~55 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form.

1. Marill, J. et al. (2000) Molecular pharmacology 58, 1341-8. PMID: 11093772
2. Lee, AJ. et al. (2003) Cancer research 63, 6532-6. PMID: 14559847
3. Barbosa-Sicard, E. et al. (2005) Biochemical and biophysical research communications 329, 1275-81. PMID: 15766564
4. Lucas, D. et al. (2010) Journal of lipid research 51, 1125-33. PMID: 19965576
5. Zeldin, DC. et al. (1995) Archives of biochemistry and biophysics 322, 76-86. PMID: 7574697
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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