

| 货号 | PTX20129 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
Anti-Human CYP2C8 Polyclonal Antibody (PTX20129) is a rabbit polyclonal antibody detecting CYP2C8, Cytochrome P450 MP-12, Cytochrome P450 IIC2, Cytochrome P450 MP-20, Cytochrome P450 2C8, CYPIIC8, S-mephenytoin 4-hydroxylase, Cytochrome P450 form 1 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 种属反应性 | Human |
| 应用 | ELISA, IHC, WB |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal |
| 同种型 | IgG |
| 免疫原 | E. coli - derived recombinant Human CYP2C8 (Gly40-Val490). |
| 靶标 | CYP2C8, Cytochrome P450 MP-12, Cytochrome P450 IIC2, Cytochrome P450 MP-20, Cytochrome P450 2C8, CYPIIC8, S-mephenytoin 4-hydroxylase, Cytochrome P450 form 1 |
| 纯化方式 | Purified by antigen affinity column. |
| Accession号 | P10632 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Cytochrome P450 2C8 (CYP2C8) is a ~55 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form. 1. Marill, J. et al. (2000) Molecular pharmacology 58, 1341-8. PMID: 11093772 2. Lee, AJ. et al. (2003) Cancer research 63, 6532-6. PMID: 14559847 3. Barbosa-Sicard, E. et al. (2005) Biochemical and biophysical research communications 329, 1275-81. PMID: 15766564 4. Lucas, D. et al. (2010) Journal of lipid research 51, 1125-33. PMID: 19965576 5. Zeldin, DC. et al. (1995) Archives of biochemistry and biophysics 322, 76-86. PMID: 7574697 |
| Note | For research use only. |

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