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| 背景 | Type II iodothyronine deiodinase (DIO2) is a ~30 kDa protein. Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine. 1. Curcio-Morelli, C. et al. (2003) Endocrinology 144, 937-46. PMID: 125867712. Buettner, C. et al. (2000) Endocrinology 141, 4606-12. PMID: 111082744. Piehl, S. et al. (2008) Rapid communications in mass spectrometry : RCM 22, 3286-96. PMID: 18821722 |
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