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Anti-Human UGCG Polyclonal Antibody (PTX20160)

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概述
货号PTX20160
品牌ProteoGenix
描述
Anti-Human UGCG Polyclonal Antibody (PTX20160) is a rabbit polyclonal antibody detecting GLCT-1, UDP-glucose ceramide glucosyltransferase, Glucosylceramide synthase, UDP-glucose:N-acylsphingosine D-glucosyltransferase, UGCG, GCS, Ceramide glucosyltransferase in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human UGCG (Gln45-Gly179).
靶标GLCT-1, UDP-glucose ceramide glucosyltransferase, Glucosylceramide synthase, UDP-glucose:N-acylsphingosine D-glucosyltransferase, UGCG, GCS, Ceramide glucosyltransferase
纯化方式Purified by antigen affinity column.
Accession号Q16739
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Ceramide glucosyltransferase (UGCG) is a ~44 kDa protein. Participates in the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway at the cytosolic surface of the Golgi. Catalyzes the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine). GlcCer is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures. Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction, implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions. They are required for instance in the proper development and functioning of the nervous system.

1. Jeckel, D. et al. (1992) The Journal of cell biology 117, 259-67. PMID: 1532799
2. Ichikawa, S. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 4638-43. PMID: 8643456
3. Boer, DE. et al. (2021) Journal of lipid research 62, 100018. PMID: 33361282
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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