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Anti-Human CHRNB4 Polyclonal Antibody (PTX20163)

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概述
货号PTX20163
品牌ProteoGenix
描述
Anti-Human CHRNB4 Polyclonal Antibody (PTX20163) is a rabbit polyclonal antibody detecting CHRNB4, Neuronal acetylcholine receptor subunit beta-4 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CHRNB4 (Arg22-Lys231).
靶标CHRNB4, Neuronal acetylcholine receptor subunit beta-4
纯化方式Purified by antigen affinity column.
Accession号P30926
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Neuronal acetylcholine receptor subunit beta-4 (CHRNB4) is a ~56 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNB4 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3 and CHRNA4, as well as CHRNA5 and CHRNB3 as accesory subunits. CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor.

1. Kuryatov, A. et al. (2011) Molecular pharmacology 79, 119-25. PMID: 20881005
2. Gharpure, A. et al. (2019) Neuron 104, 501-511.e6. PMID: 31488329
3. Wang, F. et al. (1996) The Journal of biological chemistry 271, 17656-65. PMID: 8663494
4. Elliott, KJ. et al. (1996) Journal of molecular neuroscience : MN 7, 217-28. PMID: 8906617
5. Gerzanich, V. et al. (1997) Molecular pharmacology 51, 320-7. PMID: 9203638
6. Boorman, JP. et al. (2000) The Journal of physiology 529 Pt 3, 565-77. PMID: 11118490
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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