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Anti-Human KMT2D Polyclonal Antibody (PTX20174)

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概述
货号PTX20174
品牌ProteoGenix
描述
Anti-Human KMT2D Polyclonal Antibody (PTX20174) is a rabbit polyclonal antibody detecting KMT2D, Histone-lysine N-methyltransferase 2D, Myeloid/lymphoid or mixed-lineage leukemia protein 2, ALL1-related protein, MLL4, ALR, Lysine N-methyltransferase 2D, MLL2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human KMT2D (Val5381-Met5536).
靶标KMT2D, Histone-lysine N-methyltransferase 2D, Myeloid/lymphoid or mixed-lineage leukemia protein 2, ALL1-related protein, MLL4, ALR, Lysine N-methyltransferase 2D, MLL2
纯化方式Purified by antigen affinity column.
Accession号O14686
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Histone-lysine N-methyltransferase 2D (KMT2D) is a ~593 kDa protein. Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.

1. Shinsky, SA. et al. (2015) The Journal of biological chemistry 290, 6361-75. PMID: 25561738
2. Cho, YW. et al. (2007) The Journal of biological chemistry 282, 20395-406. PMID: 17500065
3. Mo, R. et al. (2006) The Journal of biological chemistry 281, 15714-20. PMID: 16603732
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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