Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Solute carrier family 22 member 6 (SLC22A6) is a ~61 kDa protein. Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion. Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP.
1. Jung, KY. et al. (2001) Life sciences 69, 2123-35. PMID: 11669456
2. Kimura, H. et al. (2002) The Journal of pharmacology and experimental therapeutics 301, 293-8. PMID: 11907186
3. Deguchi, T. et al. (2004) Kidney international 65, 162-74. PMID: 14675047
4. Uwai, Y. et al. (2012) Pharmacological research 65, 254-60. PMID: 22108572
5. Uwai, Y. et al. (2013) Bioscience, biotechnology, and biochemistry 77, 1517-21. PMID: 23832370
6. Ohashi, A. et al. (2017) Molecular and cellular biochemistry 435, 97-108. PMID: 28534121
7. Lu, R. et al. (1999) The American journal of physiology 276, F295-303. PMID: 9950961
8. Hosoyamada, M. et al. (1999) The American journal of physiology 276, F122-8. PMID: 9887087
