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Anti-Human SMYD2 Polyclonal Antibody (PTX20245)

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概述
货号PTX20245
品牌ProteoGenix
描述
Anti-Human SMYD2 Polyclonal Antibody (PTX20245) is a rabbit polyclonal antibody detecting HSKM-B, N-lysine methyltransferase SMYD2, Histone methyltransferase SMYD2, SMYD2, SET and MYND domain-containing protein 2, Lysine N-methyltransferase 3C, KMT3C in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human SMYD2 (Met1-His433).
靶标HSKM-B, N-lysine methyltransferase SMYD2, Histone methyltransferase SMYD2, SMYD2, SET and MYND domain-containing protein 2, Lysine N-methyltransferase 3C, KMT3C
纯化方式Purified by antigen affinity column.
Accession号Q9NRG4
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

N-lysine methyltransferase SMYD2 is a ~49 kDa protein. Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53.

NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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