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Anti-Human ATP6V0A1 Polyclonal Antibody (PTX20252)

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概述
货号PTX20252
品牌ProteoGenix
描述
Anti-Human ATP6V0A1 Polyclonal Antibody (PTX20252) is a rabbit polyclonal antibody detecting V-ATPase 116 kDa subunit a1, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1, ATP6V0A1, V-type proton ATPase 116 kDa subunit a1, ATP6N1, Vacuolar proton pump subunit 1, VPP1, Vacuolar adenosine triphosphatase subunit Ac116, Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit, ATP6N1A in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ATP6V0A1 (Arg167-Arg241).
靶标V-ATPase 116 kDa subunit a1, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1, ATP6V0A1, V-type proton ATPase 116 kDa subunit a1, ATP6N1, Vacuolar proton pump subunit 1, VPP1, Vacuolar adenosine triphosphatase subunit Ac116, Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit, ATP6N1A
纯化方式Purified by antigen affinity column.
Accession号Q93050
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) is a ~96 kDa protein. Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles. In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment. Required for assembly and activity of the vacuolar ATPase. Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons.

1. Wang, L. et al. (2020) Molecular cell 80, 501-511.e3. PMID: 33065002
2. Aoto, K. et al. (2021) Nature communications 12, 2107. PMID: 33833240
3. Bott, LC. et al. (2021) Brain communications 3, fcab245. PMID: 34909687
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human ATP6V0A1 Polyclonal Antibody

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