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Anti-Human CYP46A1 Polyclonal Antibody (PTX20257)

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概述
货号PTX20257
品牌ProteoGenix
描述
Anti-Human CYP46A1 Polyclonal Antibody (PTX20257) is a rabbit polyclonal antibody detecting Cholesterol 24-hydroxylase, Cholesterol 24-monooxygenase, CH24H, CYP46A1, Cytochrome P450 46A1, CYP46, Cholesterol 24S-hydroxylase in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CYP46A1 (His45-Cys500).
靶标Cholesterol 24-hydroxylase, Cholesterol 24-monooxygenase, CH24H, CYP46A1, Cytochrome P450 46A1, CYP46, Cholesterol 24S-hydroxylase
纯化方式Purified by antigen affinity column.
Accession号Q9Y6A2
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cholesterol 24-hydroxylase (CYP46A1) is a ~56 kDa protein. P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation. By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning. Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis. Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain.

1. Lund, EG. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 7238-43. PMID: 10377398
2. Mast, N. et al. (2003) Biochemistry 42, 14284-92. PMID: 14640697
3. Mast, N. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 9546-51. PMID: 18621681
4. Goyal, S. et al. (2014) Journal of lipid research 55, 1933-43. PMID: 25017465
5. Bodin, K. et al. (2002) The Journal of biological chemistry 277, 31534-40. PMID: 12077124
6. Mast, N. et al. (2017) The Journal of biological chemistry 292, 4913-4924. PMID: 28190002
7. Mast, N. et al. (2010) The Journal of biological chemistry 285, 31783-95. PMID: 20667828
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human CYP46A1 Polyclonal Antibody

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