Anti-Human CD59 Polyclonal Antibody (PTX20264) is a rabbit polyclonal antibody detecting CD59 in ELISA, IHC, WB. Suitable for Pongo abelii, Homo sapiens.
Highlights
Affinity Purified — Minimal background and high purity for reliable results.
Multi-Application — Validated across multiple applications.
Multi-Species — Cross-reactive for translational research.
种属反应性
Pongo abelii, Homo sapiens
应用
ELISA, IHC, WB
宿主
Rabbit
克隆类型
Polyclonal
同种型
IgG
免疫原
E. coli - derived recombinant Human CD59 (Ser25-Pro128).
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -142°C for twelve months from the date of receipt.
CD59 glycoprotein is a ~14 kDa protein. Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation. Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore.
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4. Davies, A. et al. (1989) The Journal of experimental medicine 170, 637-54. PMID: 2475570
5. Sugita, Y. et al. (1989) Journal of biochemistry 106, 555-7. PMID: 2606909
6. Bodian, DL. et al. (1997) The Journal of experimental medicine 185, 507-16. PMID: 9053451
