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Anti-Human GLRA1 Polyclonal Antibody (PTX20279)

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概述
货号PTX20279
品牌ProteoGenix
描述
Anti-Human GLRA1 Polyclonal Antibody (PTX20279) is a rabbit polyclonal antibody detecting Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit, Glycine receptor subunit alpha-1, GLRA1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human GLRA1 (Ala32-Gln247).
靶标Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit, Glycine receptor subunit alpha-1, GLRA1
纯化方式Purified by antigen affinity column.
Accession号P23415
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Glycine receptor subunit alpha-1 (GLRA1) is a ~52 kDa protein. Subunit of heteromeric glycine-gated chloride channels. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol. Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol.

1. Mohammadi, B. et al. (2003) European biophysics journal : EBJ 32, 529-36. PMID: 14551753
2. Mowrey, DD. et al. (2013) Structure (London, England : 1993) 21, 1897-904. PMID: 23994010
3. Moraga-Cid, G. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 2865-70. PMID: 25730860
4. Liu, X. et al. (2023) Nature communications 14, 6377. PMID: 37821459
5. Shiang, R. et al. (1993) Nature genetics 5, 351-8. PMID: 8298642
6. Lynch, JW. et al. (1997) The EMBO journal 16, 110-20. PMID: 9009272
7. Zhang, Y. et al. (2015) Neuropharmacology 89, 391-7. PMID: 25445488
8. Horani, S. et al. (2015) Alcoholism, clinical and experimental research 39, 962-8. PMID: 25973519
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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