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Anti-BMP2 Polyclonal Antibody (PTX20322)

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概述
货号PTX20322
品牌ProteoGenix
描述
Anti-BMP2 Polyclonal Antibody (PTX20322) is a rabbit polyclonal antibody detecting BMP-2, BMP2A, Bone morphogenetic protein 2A, Bone morphogenetic protein 2, BMP2, BMP-2A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human BMP2 (Gln283-Arg396).
靶标BMP-2, BMP2A, Bone morphogenetic protein 2A, Bone morphogenetic protein 2, BMP2, BMP-2A
纯化方式Purified by antigen affinity column.
Accession号P12643
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Bone morphogenetic protein 2 (BMP2) is a ~44 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.

1. Lavery, K. et al. (2008) The Journal of biological chemistry 283, 20948-58. PMID: 18436533
2. Tanaka, K. et al. (2014) Calcified tissue international 94, 454-64. PMID: 24362451
3. Seeherman, HJ. et al. (2019) Science translational medicine 11. PMID: 31019025
4. Wozney, JM. et al. (1988) Science (New York, N.Y.) 242, 1528-34. PMID: 3201241
5. Keller, S. et al. (2004) Nature structural & molecular biology 11, 481-8. PMID: 15064755
6. Weber, D. et al. (2007) BMC structural biology 7, 6. PMID: 17295905
7. Liu, F. et al. (1995) Molecular and cellular biology 15, 3479-86. PMID: 7791754
8. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957
9. Tsukahara, S. et al. (2006) The Biochemical journal 398, 595-603. PMID: 16771708
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-BMP2 Polyclonal Antibody

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