| 背景 | Toll-like receptor 8 (CD288/TLR8) is a ~119 kDa protein. Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively. 1. Ishii, N. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 193, 5118-28. PMID: 252978765. Tanji, H. et al. (2013) Science (New York, N.Y.) 339, 1426-9. PMID: 235201116. Tanji, H. et al. (2015) Nature structural & molecular biology 22, 109-15. PMID: 255993977. Tanji, H. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, 3012-7. PMID: 269293718. Qin, J. et al. (2006) The Journal of biological chemistry 281, 21013-21021. PMID: 167379609. Doyle, SL. et al. (2007) The Journal of biological chemistry 282, 36953-60. PMID: 17932028 |
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