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Anti-NPC1 Polyclonal Antibody (PTX20350)

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概述
货号PTX20350
品牌ProteoGenix
描述
Anti-NPC1 Polyclonal Antibody (PTX20350) is a rabbit polyclonal antibody detecting NPC intracellular cholesterol transporter 1, Niemann-Pick C1 protein, NPC1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human NPC1 (Arg372-Phe622).
靶标NPC intracellular cholesterol transporter 1, Niemann-Pick C1 protein, NPC1
纯化方式Purified by antigen affinity column.
Accession号O15118
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

NPC intracellular cholesterol transporter 1 (NPC1) is a ~142 kDa protein. Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).

1. Davies, JP. et al. (2000) The Journal of biological chemistry 275, 24367-74. PMID: 10821832
2. Blom, TS. et al. (2003) Human molecular genetics 12, 257-72. PMID: 12554680
3. Infante, RE. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 15287-92. PMID: 18772377
4. Gong, X. et al. (2016) Cell 165, 1467-1478. PMID: 27238017
5. Carstea, ED. et al. (1997) Science (New York, N.Y.) 277, 228-31. PMID: 9211849
6. Watari, H. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 805-10. PMID: 9927649
7. Kwon, HJ. et al. (2009) Cell 137, 1213-24. PMID: 19563754
8. Ebrahimi-Fakhari, D. et al. (2016) Human molecular genetics 25, 3588-3599. PMID: 27378690
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-NPC1 Polyclonal Antibody

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