Bile salt export pump (ABCB11) is a ~146 kDa protein. Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates in hepatic bile acid homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion. 1. Hayashi, H. et al. (2005) Hepatology (Baltimore, Md.) 41, 916-24. PMID: 157916182. Hayashi, H. et al. (2005) Biochimica et biophysica acta 1738, 54-62. PMID: 163324563. Yabuuchi, H. et al. (2008) Biopharmaceutics & drug disposition 29, 441-8. PMID: 189857984. Paulusma, CC. et al. (2009) The Journal of biological chemistry 284, 9947-54. PMID: 192286925. Ho, RH. et al. (2010) Pharmacogenetics and genomics 20, 45-57. PMID: 200103826. Kato, T. et al. (2010) Biochimica et biophysica acta 1801, 1005-12. PMID: 203987917. Hayashi, H. et al. (2012) Hepatology (Baltimore, Md.) 55, 1889-900. PMID: 222624668. Guyot, C. et al. (2014) Molecular pharmacology 85, 909-20. PMID: 247111189. Imagawa, K. et al. (2018) Journal of human genetics 63, 569-577. PMID: 29507376 | 
