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Anti-PSMB8 Polyclonal Antibody (PTX20383)

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概述
货号PTX20383
品牌ProteoGenix
描述
Anti-PSMB8 Polyclonal Antibody (PTX20383) is a rabbit polyclonal antibody detecting Low molecular mass protein 7, Macropain subunit C13, Really interesting new gene 10 protein, RING10, LMP7, Y2, Proteasome component C13, PSMB5i, Multicatalytic endopeptidase complex subunit C13, Proteasome subunit beta-5i, Proteasome subunit beta type-8, PSMB8 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human PSMB8 (Thr75-Ser261).
靶标Low molecular mass protein 7, Macropain subunit C13, Really interesting new gene 10 protein, RING10, LMP7, Y2, Proteasome component C13, PSMB5i, Multicatalytic endopeptidase complex subunit C13, Proteasome subunit beta-5i, Proteasome subunit beta type-8, PSMB8
纯化方式Purified by antigen affinity column.
Accession号P28062
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Proteasome subunit beta type-8 (PSMB8) is a ~30 kDa protein. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein.

1. Ebstein, F. et al. (2016) Scientific reports 6, 24032. PMID: 27049119
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-PSMB8 Polyclonal Antibody

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