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Anti-ABCB7 Polyclonal Antibody (PTX20405)

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概述
货号PTX20405
品牌ProteoGenix
描述
Anti-ABCB7 Polyclonal Antibody (PTX20405) is a rabbit polyclonal antibody detecting ABC transporter 7 protein, ABC7, ATP-binding cassette sub-family B member 7, mitochondrial, ATP-binding cassette transporter 7, ABCB7 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ABCB7 (Val472-Cys752).
靶标ABC transporter 7 protein, ABC7, ATP-binding cassette sub-family B member 7, mitochondrial, ATP-binding cassette transporter 7, ABCB7
纯化方式Purified by antigen affinity column.
Accession号O75027
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Iron-sulfur clusters transporter ABCB7, mitochondrial is a ~82 kDa protein. Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis. Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis. In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1. May also play a role in hematopoiesis.

1. Allikmets, R. et al. (1999) Human molecular genetics 8, 743-9. PMID: 10196363
2. Cavadini, P. et al. (2007) Blood 109, 3552-9. PMID: 17192393
3. Pearson, SA. et al. (2021) Archives of biochemistry and biophysics 697, 108661. PMID: 33157103
4. Maio, N. et al. (2019) Haematologica 104, 1756-1767. PMID: 30765471
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-ABCB7 Polyclonal Antibody

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