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Anti-Human SLC22A12 Polyclonal Antibody (PTX20437)

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概述
货号PTX20437
品牌ProteoGenix
描述
Anti-Human SLC22A12 Polyclonal Antibody (PTX20437) is a rabbit polyclonal antibody detecting Urate anion exchanger 1, Organic anion transporter 4-like protein, OATL4, Solute carrier family 22 member 12, RST, URAT1, SLC22A12, Renal-specific transporter in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human SLC22A12 (Glu281-Thr350).
靶标Urate anion exchanger 1, Organic anion transporter 4-like protein, OATL4, Solute carrier family 22 member 12, RST, URAT1, SLC22A12, Renal-specific transporter
纯化方式Purified by antigen affinity column.
Accession号Q96S37
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Solute carrier family 22 member 12 (SLC22A12) is a ~59 kDa protein. Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption.

1. Enomoto, A. et al. (2002) Nature 417, 447-52. PMID: 12024214
2. Tasic, V. et al. (2011) PloS one 6, e28641. PMID: 22194875
3. Shinoda, Y. et al. (2022) Drug metabolism and pharmacokinetics 43, 100443. PMID: 35144162
4. Toyoda, Y. et al. (2022) Frontiers in pharmacology 13, 842717. PMID: 35462902
5. Miura, D. et al. (2011) The journal of physiological sciences : JPS 61, 253-7. PMID: 21350910
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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