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Anti-Mouse SIGLEC10/SLG2 Polyclonal Antibody (PTX20616)

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概述
货号PTX20616
品牌ProteoGenix
描述
Anti-Mouse SIGLEC10/SLG2 Polyclonal Antibody (PTX20616) is a rabbit polyclonal antibody detecting Sialic acid-binding Ig-like lectin 10 (Siglec-10) (Sialic acid-binding Ig-like lectin G) (Siglec-G) (mSiglec-G) in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Mouse
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Mouse SIGLEC10/SLG2 (Gln18-Ser528).
靶标Sialic acid-binding Ig-like lectin 10 (Siglec-10) (Sialic acid-binding Ig-like lectin G) (Siglec-G) (mSiglec-G)
纯化方式Purified by antigen affinity column.
Accession号Q80ZE3
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Sialic acid-binding Ig-like lectin 10 (SIGLEC10/SLG2) is a ~76 kDa protein. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling and specifically acts on B1 cells to inhibit Ca(2+) signaling, cellular expansion and antibody secretion.

1. Duong, BH. et al. (2010) The Journal of experimental medicine 207, 173-87. PMID: 20038598
2. Hoffmann, A. et al. (2007) Nature immunology 8, 695-704. PMID: 17572677
3. Pfrengle, F. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 1724-31. PMID: 23836061
4. Chen, GY. et al. (2009) Science (New York, N.Y.) 323, 1722-5. PMID: 19264983
5. Jellusova, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 3618-27. PMID: 20200274
6. Ding, Y. et al. (2016) Nature immunology 17, 1167-75. PMID: 27548433
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Mouse SIGLEC10/SLG2 Polyclonal Antibody

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