| 背景 | C-type lectin domain family 7 member A (CD369/CLEC7A) is a ~27 kDa protein. Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. 2. Adachi, Y. et al. (2004) Infection and immunity 72, 4159-71. PMID: 152131613. Taylor, PR. et al. (2007) Nature immunology 8, 31-8. PMID: 171599844. Gantner, BN. et al. (2003) The Journal of experimental medicine 197, 1107-17. PMID: 127194795. Viriyakosol, S. et al. (2005) Infection and immunity 73, 1553-60. PMID: 157310537. Campuzano, A. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 204, 3296-3306. PMID: 32358020 |
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