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Anti-GSK3A Polyclonal Antibody (PTX20062)

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概述
货号PTX20062
品牌ProteoGenix
描述
Anti-GSK3A Polyclonal Antibody (PTX20062) is a rabbit polyclonal antibody detecting GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinase GSK3A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human GSK3A (Lys99-Ser483).
靶标GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 alpha, Serine/threonine-protein kinase GSK3A
纯化方式Purified by antigen affinity column.
Accession号P49840
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Glycogen synthase kinase-3 alpha (GSK3A) is a ~50 kDa protein. Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors.

1. Ali, A. et al. (2001) Chemical reviews 101, 2527-40. PMID: 11749387
2. Lee, J. et al. (2007) Diabetes research and clinical practice 77 Suppl 1, S49-57. PMID: 17478001
3. Rayasam, GV. et al. (2009) British journal of pharmacology 156, 885-98. PMID: 19366350
4. Nikoulina, SE. et al. (2000) Diabetes 49, 263-71. PMID: 10868943
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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