注册
CN
首页 > 产品中心 > 抗体 > 一抗

Anti-Mouse PCSK9 Antibody (mAb1) (PTX19171)

价格:
规格：
数量：
联系我们
一键复制产品信息

  • 概述

  • 图片

  • 参考文献

概述
货号PTX19171
品牌ProteoGenix
描述
Anti-Mouse PCSK9 Antibody (mAb1) [mAb1] (PTX19171) is a rat monoclonal antibody detecting Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9, NARC-1, PC9, Proprotein convertase 9, Neural apoptosis-regulated convertase 1, NARC1, PCSK9 in Blocking, ELISA. Suitable for Human, Mouse, Monkey.
Highlights
  • Protein A/G purified from cell culture supernatant. — Ensuring high specificity and minimal background.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Monkey
应用Blocking, ELISA
宿主Rat
克隆类型Monoclonal
同种型IgG1, kappa
克隆号mAb1
靶标Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9, NARC-1, PC9, Proprotein convertase 9, Neural apoptosis-regulated convertase 1, NARC1, PCSK9
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q80W65
状态Liquid
保存溶液 0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a ~74 kDa protein. Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. PCSK9 is the therapeutic target of evolocumab (Repatha).

NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

相关产品推荐

获取报价

Anti-Mouse PCSK9 Antibody (mAb1)

  • 7X24小时产品咨询热线：027--87433958(9:00-18:00)，或扫描下方产品专员二维码或在线留言

  • 武汉东湖新技术开发区神墩四路666号研发楼B区3层东

  • 24小时产品查询

    24小时产品查询

  • 24小时产品查询

    扫一扫关注我们

  • 24小时产品查询

    专属渠道经理

Copyright © 2026 武汉艾必赛生物科技有限公司版权所有 所有产品仅可用于工业或者科研等非医疗目的。
鄂ICP备2023002448号-2