Potassium voltage-gated channel subfamily B member 1 (p-KCNB1) is a ~95 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Also plays a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. 1. Murakoshi, H. et al. (1999) The Journal of neuroscience : the official journal of the Society for Neuroscience 19, 1728-35. PMID: 100243592. Du, J. et al. (2000) The Journal of physiology 522 Pt 1, 19-31. PMID: 106181493. Malin, SA. et al. (2002) The Journal of neuroscience : the official journal of the Society for Neuroscience 22, 10094-105. PMID: 124511104. Guan, D. et al. (2007) The Journal of physiology 581, 941-60. PMID: 173796385. Mohapatra, DP. et al. (2009) Channels (Austin, Tex.) 3, 46-56. PMID: 192766636. Guan, D. et al. (2013) The Journal of physiology 591, 4807-25. PMID: 238783737. Feinshreiber, L. et al. (2010) Journal of cell science 123, 1940-7. PMID: 204846658. Ju, M. et al. (2003) The Journal of biological chemistry 278, 12769-78. PMID: 125603409. Taglialatela, M. et al. (1991) Molecular pharmacology 40, 299-307. PMID: 1875913 | 
