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Anti-Human GluA2 Antibody (L21/32R) (PTX19258)

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概述
货号PTX19258
品牌ProteoGenix
描述
Anti-Human GluA2 Antibody (L21/32R) [L21/32R] (PTX19258) is a mouse monoclonal antibody detecting GluR-2, AMPA-selective glutamate receptor 2, GluR-B, Glutamate receptor 2, GLUR2, GRIA2, GluA2, Glutamate receptor ionotropic, AMPA 2, GluR-K2 in IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Protein A/G purified from cell culture supernatant. — Ensuring high specificity and minimal background.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用IHC, WB
宿主Mouse
克隆类型Monoclonal
同种型IgG2a, kappa
克隆号L21/32R
靶标GluR-2, AMPA-selective glutamate receptor 2, GluR-B, Glutamate receptor 2, GLUR2, GRIA2, GluA2, Glutamate receptor ionotropic, AMPA 2, GluR-K2
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P42262, P23819, P19491
状态Liquid
保存溶液 0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景

Glutamate receptor 2 (GRIA2/GluR-2) is a ~98 kDa protein. Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate.

1. Ward, SE. et al. (2010) Journal of medicinal chemistry 53, 5801-12. PMID: 20614889
2. Salpietro, V. et al. (2019) Nature communications 10, 3094. PMID: 31300657
3. Sun, W. et al. (1994) Neuroreport 5, 441-4. PMID: 8003671
4. Kolleker, A. et al. (2003) Neuron 40, 1199-212. PMID: 14687553
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human GluA2 Antibody (L21/32R)

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