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Anti-Human CD289/TLR9 Antibody (5G5) (PTX19286)

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概述
货号PTX19286
品牌ProteoGenix
描述
Anti-Human CD289/TLR9 Antibody (5G5) [5G5] (PTX19286) is a mouse monoclonal antibody detecting CD289, TLR9, Toll-like receptor 9 in IF, IP, WB. Suitable for Human.
Highlights
  • Protein A/G purified from cell culture supernatant. — Ensuring high specificity and minimal background.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用IF, IP, WB
宿主Mouse
同种型IgG2a, lambda
克隆号5G5
克隆类型Monoclonal
靶标CD289, TLR9, Toll-like receptor 9
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q9NR96
状态Liquid
保存溶液 0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景

Toll-like receptor 9 (CD289/TLR9) is a ~115 kDa protein. Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also acts via ADCY7, leading to cyclic di-AMP (c-di-AMP) synthesis and activation of the NLRP3 inflammasome.

1. Latz, E. et al. (2004) Nature immunology 5, 190-8. PMID: 14716310
2. Takeshita, F. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 3555-8. PMID: 11564765
3. Doyle, SL. et al. (2007) The Journal of biological chemistry 282, 36953-60. PMID: 17932028
4. Li, FJ. et al. (2013) European journal of immunology 43, 2980-92. PMID: 23857366
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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