首页 > 产品中心 > 抗体 > 一抗

Anti-Human CACNA1C Antibody (L57/46R) (PTX19381)

价格:
规格:
数量:
  • 概述

  • 图片

  • 参考文献

概述
货号PTX19381
品牌ProteoGenix
描述
Highlights
  • Protein A/G purified from cell culture supernatant. — Ensuring high specificity and minimal background.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用IHC, IP, WB
宿主Mouse
克隆类型Monoclonal
同种型IgG2a
克隆号L57/46R
靶标Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1, Voltage-dependent L-type calcium channel subunit alpha-1C, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, Rat brain class C, RBC, Voltage-gated calcium channel subunit alpha Cav1.2
内毒素水平Please contact with the lab for this information.
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q13936
状态Liquid
保存溶液 0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

稳定性和存储Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
背景

Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) is a ~248 kDa protein. Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine.

1. Qin, N. et al. (2002) Molecular pharmacology 62, 485-96. PMID: 12181424
2. Splawski, I. et al. (2004) Cell 119, 19-31. PMID: 15454078
3. Splawski, I. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8089-96; discussion 8086-8. PMID: 15863612
4. Van Petegem, F. et al. (2005) Nature structural & molecular biology 12, 1108-15. PMID: 16299511
5. Antzelevitch, C. et al. (2007) Circulation 115, 442-9. PMID: 17224476
6. Kim, EY. et al. (2010) The EMBO journal 29, 3924-38. PMID: 20953164
7. Boczek, NJ. et al. (2013) Circulation. Cardiovascular genetics 6, 279-89. PMID: 23677916
8. Fukuyama, M. et al. (2014) Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 16, 1828-37. PMID: 24728418
9. Boczek, NJ. et al. (2015) Circulation. Arrhythmia and electrophysiology 8, 1122-32. PMID: 26253506
10. Sutphin, BS. et al. (2016) Congenital heart disease 11, 683-692. PMID: 27218670
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量,自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项,自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

相关产品推荐