

| 货号 | HW820013 | ||||
|---|---|---|---|---|---|
| 品牌 | abinScience | ||||
| 描述 |
Anti-Human CDKN2A/p16INK4a Nanobody (SAA2259) [SAA2259] (HW820013) is a alpaca monoclonal antibody detecting CDKN2A/p16INK4a in ELISA. Suitable for Human.
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| 种属反应性 | Human | ||||
| 应用 | ELISA | ||||
| 宿主 | Alpaca | ||||
| 同种型 | VHH-His | ||||
| 克隆号 | SAA2259 | ||||
| 克隆类型 | Monoclonal | ||||
| 靶标 | CDKN2A/p16INK4a | ||||
| 内毒素水平 | Please contact with the lab for this information. | ||||
| 纯度 | >90% as determined by SDS-PAGE. | ||||
| 纯化方式 | Protein A/G purified from cell culture supernatant. | ||||
| Accession号 | Q8N726 | ||||
| 状态 | Liquid | ||||
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 别名 | Tumor suppressor ARF, Alternative reading frame, ARF, Cyclin-dependent kinase inhibitor 2A, p14ARF, CDKN2A | ||||
| 背景 | Tumor suppressor ARF (CDKN2A/p16INK4a) is a ~13 kDa protein. Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. | ||||
| Note | For research use only. |

SDS-PAGE for Anti-Human CDKN2A/p16INK4a Nanobody (SAA2259)



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